Wellbutrin is prescribed to treat major depressive disorder and prevent seasonal affective disorder. Learn about the drug’s dosages and more. The FDA investigated these complaints and concluded that Budeprion XL is equivalent to Wellbutrin XL regarding bioavailability of bupropion and its main active metabolite hydroxybupropion. Wellbutrin (bupropion) is used to treat major depressive disorder and seasonal affective disorder. Includes Wellbutrin side effects, interactions and indications. Learn about the side effects of Wellbutrin (bupropion), from common to rare, for consumers and healthcare professionals. What is Wellbutrin? Wellbutrin is the brand name for bupropion and the active ingredient in Wellbutrin is bupropion hydrochloride (bupropion HCl). It’s commonly used to treat major depression and seasonal affective disorder or SAD. It’s also used to aid in smoking cessation. Find patient medical information for Bupropion (Wellbutrin, Zyban, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings The official site for WELLBUTRIN XL® provides information for healthcare professionals on clinical experience in Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). Bupropion is used to treat major depressive disorder (MDD) and to prevent seasonal affective disorder (SAD), which is sometimes called autumn-winter seasonal depression. It is also used as part of a support program to help people stop smoking. Bupropion is sold under different brand names. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation). Symptoms of depression include: SAD is a type of depression that occurs mainly during the autumn-winter season. Wellbutrin is an orally administered, brand-name product for treating major depressive disorder (MDD), seasonal affective disorder (SAD), and smoking cessation.